Liposomes constituted from light-sensitive lipids have been explored since early 1980s. Membrane permeabilization of these light-controlled liposomes are induced upon light exposure of specific wavelength to target drug release. A successful example of photo-activated liposome formulation in clinical use now is Visudyne therapy to treat age-related macular degeneration of (AMD) in patients. In this formulation, essential drug release is followed by non-photothermal treatment with a 689 nm laser source after injection. As a candidate for sustained and on demand drug delivery, photo-activated liposomes gained more attention with its various parameters, such as exposure time, wavelength, beam diameter, and laser intensity to adapt to different purposes. Creative Biostructure can facilitate such effort with high quality service.
Photo-activated Liposomes Applications
The fact that spatial and temporal release of nanoparticle-encapsulated drugs is triggered at the site of action calls for attention to further improve drug delivery sustainability, and Photo-Stabilized Liposomes is one of the approaches to sustained drug delivery utilizing photoreactive lipids. Photo-activated Liposomes with built-in photo triggering properties will have significant impact on cancer therapy and other related diseases.
