What Are The Three Steps In Tissue Repair?


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Inflammation- Severed blood vessels bleed and inflammatory chemicals are released. Local blood vessels become more permeable, allowing white blood cells, fluid, clotting proteins and other plasma proteins to seep into the injured area. Clotting occurs; surface dries and forms a scab.

Organization restores the blood supply- The clot is replaced by granulation tissue, which restores the vascular supply. Fibroblasts produce collagen fibers that bridge the gap. Macrophages phagocytes the cell debris. Surface epithelial cells multiply and migrate over the granulation tissues.

Regeneration and fibrosis effect permanent repair- the fibrosis area matures and contracts; the epithelium thickens. A fully regenerated epithelium with an underlying area of scar tissue results.

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