PH can denature enzymes because a enzyme is held together by hydrogen bonds.If you make an enzymes environment more acidic, more H+ ions are added, this disrupts the hydrogen bonds of the enzyme and denature it.
How Does PH Affect The Activity Of An Enzyme?
Every enzyme has an optimum pH level and this is different for different kinds of enzymes. PH affects enzymes in many ways.
Affects of pH on Enzymes: A change in the pH can change the shape of the enzyme. Changes in the substrate of the enzyme can also occur which would either disable the substrate from binding or make it unable to go through catalysis. When the pH reaches a very high level, it is called Alkalosis. When this happens, the enzyme’s function gets disrupted and they can't perform effectively.
Affects of pH on Enzymes: A change in the pH can change the shape of the enzyme. Changes in the substrate of the enzyme can also occur which would either disable the substrate from binding or make it unable to go through catalysis. When the pH reaches a very high level, it is called Alkalosis. When this happens, the enzyme’s function gets disrupted and they can't perform effectively.
It changes it functional structure, so that the substrate will no longer fit