What Are The Major Harmful Effects Of Ozone Depletion?

It can cause skin cancer and also blindness.

^^You're stupid, there are a million harmful effects of the holes in  the ozone layer. An increased amount of ultraviolet light reaches Earth from the Sun. Plus, loss of the ozone layer causes the exposition of UVB rays, which are harmful to human health and to the environment. UVB rays have the harmful effects such as causing skin cancers, cataracts, and it harms crops, certain materials, and some forms of marine life.
So yeah, those are a few of the harmful effects of the ozone depletion :)