Advantages and disadvantages of non-random sampling?

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Duane Bryant answered
One ADVANTAGE of non-random sampling is that you can choose the sampling to reflect the results you WANT to obtain.  If I want to make a hypothesis and prove it, I only sample the specimens that support my hypothesis.
One DISADVANTAGE of true random sampling is that it may not be helpful in finding an answer to the problem.  If I want to find a cure to cancer, it is much more helpful (and efficient) to sample people who HAVE cancer.  Of course you still need to sample people without cancer to see differences.

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