With the in-depth study of enzymes and more and more understanding, complex enzymes rich in high-concentration SOD have played an increasingly significant role in the conditioning of diseases.
Enzyme therapy has gradually been recognized, and the application of various enzyme preparations in clinical practice is becoming more and more common. Such as trypsin, chymotrypsin, etc., can catalyze the decomposition of proteins, this principle has been used for surgical expansion, suppurative wound purification and treatment of thoracic and intraperitoneal serosal adhesions. In the treatment of thrombophlebitis, myocardial infarction, pulmonary infarction, and disseminated intravascular coagulation, plasmin, streptokinase, and urokinase can be used to dissolve blood clots and prevent the formation of blood clots.
The yeast used in the wine industry is produced by related microorganisms. The action of enzymes passes starch, etc. Through hydrolysis, oxidation and other processes, and finally into alcohol; the production of soy sauce and vinegar is also carried out under the action of enzymes; Amylase and cellulase treated feeds have improved nutritional value.
Biocatalysts can be developed based on rational design, in which the effect of structural changes on catalytic behaviors are predicted through physical models. This is usually contrasted with directed evolution. To achieve rational design, the structural and functional relationship should be understood based on studies of natural enzymes. Natural biocatalysts have relatively narrow functionalities because the types of cofactors and naturally occurring amino acids are limited. Therefore, many efforts of rational design are made to design artificial enzymes beyond nature. For example, many approaches for metalloenzymes are developed, such as metal substitution, metal cofactors replacement, and unnatural amino acids (UAAs) incorporation in native or de novo protein scaffolds, as well as with the help of computational designs.